アンプラット社とディグザイム社、データと酵素技術で提携

株式会社アンプラットは、Digzyme Inc.

As part of this initiative, in collaboration with digzyme Inc., a group of experts in enzyme discovery and improvement, Amprat has announced the launch of “digzyme in silico DMS (Deep Mutational Scanning),” an analysis service on its data analysis technology sharing platform, “ANCAT,” which predicts with high accuracy the activity of enzyme mutants and the function of single mutants of enzymes for precision fermentation and in vitro diagnostics.

かたい肉をやわらかくしたり、洗剤の洗浄効果を高めたりと、私たちの生活を快適にしてくれる物質「酵素」。生命科学の研究成果として、最も身近で社会に還元されている物質と言えるでしょう。しかし、酵素の研究はとても難しく、時間もかかります。実際、現在実用化されている酵素の多くは、研究の過程で偶然発見されたもので、はっきり言ってしまえば、偶然を待つしかないのが現状です。

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こちらもお読みください： Nuclera社、APACおよび中東で販売網を拡大

酵素は20種類、約100～1000個のアミノ酸が連なったタンパク質の一種ですが、人工的に変異体（アミノ酸置換体）を作るのは手間のかかる作業です。ひとつひとつの変異とその組み合わせを考えると、候補は膨大な数になり、計算で絞り込むには高度な専門技術と計算資源が必要です。

The single mutant function prediction analysis service “digzyme in silico DMS (Deep Mutational Scanning)” for precision fermentation and in vitro diagnostic enzymes, which was recently released within the data analysis technology sharing platform “ANCAT,” makes it easy to predict the function of single mutants for precision fermentation and in vitro diagnostic enzymes. Since the analysis work is performed by the researchers themselves, it is relatively inexpensive compared to general contract analysis, and data analysis can be performed seamlessly in line with the progress of the research.

In order to overcome the current situation where there is a shortage of personnel capable of data analysis in the field, which causes research to stagnate and many laboratories and research teams to be troubled by the high cost of outsourcing analysis, Amplat has developed and operates a platform called “ANCAT” that allows researchers themselves to easily perform analysis even without specialized computing technology knowledge. This collaboration combines the advanced bioinformatics technology shared by both companies, and further combines アンプラット‘s “power of generalization” using its high IT skills with 消化酵素‘s “expertise in enzyme discovery,” as one of the solutions to realize digzyme’s mission of “Let’s go and meet enzymes that will change the world.”

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